張 政

教授，博士生導(dǎo)師

藥理學(xué)系

電話(huà)：0731-82355077

傳真：0731-82355078

電子郵箱：zzhang@csu.edu.cn,zzhang510@gmail.com

學(xué)習(xí)工作經(jīng)歷

1998/09–2003/07，武漢大學(xué)，臨床醫(yī)學(xué)本科

2003/09–2008/07，中山大學(xué)，心血管藥理學(xué)碩博連讀

2008/09–2009/12，University of Connecticut Health Center，離子通道藥理學(xué)博士后

2010/01–2013/01，The Queen’s Medical Center，離子通道藥理學(xué)博士后

2013/02–至今，中南大學(xué)湘雅藥學(xué)院藥理學(xué)系

研究領(lǐng)域

心血管離子通道藥理學(xué)；離子通道生物物理學(xué)；鈣離子信號(hào)轉(zhuǎn)導(dǎo)

部分發(fā)表論文

1.Huang EW, Liu CZ, Liang SJ,Zhang Z, Lv XF, Liu J, Zhou JG, Tang YB, Guan YY. Endophilin-A2-mediated increase in scavenger receptor expression contributes to macrophage-derived foam cell formation.Atherosclerosis.2016; 254:133-141.

2.Sponder G, Mastrototaro L, Kurth K, Merolle L,Zhang Z, Abdulhanan N, Smorodchenko A, Wolf K, Fleig A, Penner R, Iotti S, Aschenbach JR, Vormann J, Kolisek M. Human CNNM2 is not a Mg²⁺transporter per se.Pflugers Arch.2016; 468(7):1223-40.

3.Wang M, Tang YB, Ma MM, Chen JH, Hu CP, Zhao SP, Peng DQ, Zhou JG, Guan YY,Zhang Z. TRPC3 channel confers cerebrovascular remodelling during hypertension via transactivation of EGF receptor signalling.Cardiovasc Res.2016; 109(1):34-43.

4.Zhang Z, Faouzi M, Huang J, Geerts D, Yu H, Fleig A, Penner R. N-Myc-induced up-regulation of TRPM6/TRPM7 channels promotes neuroblastoma cell proliferation.Oncotarget. 2014; 5(17):7625-34.

5.Zhang Z, Yu H, Huang J, Faouzi M, Schmitz C, Penner R, Fleig A. The TRPM6 kinase domain determines the MgATP-sensitivity of TRPM7/M6 heteromeric ion channels.J Biol Chem. 2014; 289(8):5217-27

6.Yu H,Zhang Z, Lis A, Penner R, Fleig A. TRPM7 is regulated by halides through its kinase domain.Cell Mol Life Sci.2013; 70(15):2757-71

7.Zhang Z, Wang M, Fan XH, Chen JH, Guan YY, Tang YB. Upregulation of TRPM7 channels by angiotensin II triggers phenotypic switching of vascular smooth muscle cells of ascending aorta.Circ Res. 2012;111(9):1137-46

8.Wang M, Yang H, Zheng LY,Zhang Z, Tang YB, Wang GL, Du YH, Lv XF, Liu J, Zhou JG, Guan YY. Downregulation of TMEM16A calcium-activated chloride channel contributes to cerebrovascular remodeling during hypertension by promoting basilar smooth muscle cell proliferation.Circulation. 2012;125:697-707

9.Shi XL, Wang GL,Zhang Z, Liu YJ, Chen JH, Zhou JG, Qiu QY, Guan YY. Alteration of volume-regulated chloride movement in rat cerebrovascular smooth muscle cells during hypertension.Hypertension.2007;49:1371-1377

10.Zierler S, Yao G,Zhang Z, Kuo WC, Porzgen P, Penner R, Horgen FD, Fleig A. Waixenicin a inhibits cell proliferation through magnesium-dependent block of transient receptor potential melastatin 7 (TRPM7) channels.J Biol Chem. 2011;286:39328-39335

11.Du J, Xie J,Zhang Z, Tsujikawa H, Fusco D, Silverman D, Liang B, Yue L. TRPM7-mediated Ca²⁺signals confer fibrogenesis in human atrial fibrillation.Circ Res. 2010;106:992-1003

12.Chen HC, Xie J,Zhang Z, Su LT, Yue L, Runnels LW.Blockade of TRPM7 channel activity and cell death by inhibitors of 5-lipoxygenase.PLoS One. 2010;5:e11161