朱曲波，1981年1月生，中南大學(xué)，湘雅藥學(xué)院藥劑學(xué)系，教授。

朱曲波博士，湖南長沙人。2003年本科畢業(yè)于武漢大學(xué)；2009年博士畢業(yè)于美國Texas A&M University；并在美國Case Western Reserve University知名教授Krzysztof Palczewski實(shí)驗(yàn)室從事博士后研究工作。2011年以升華獵英計(jì)劃引入中南大學(xué)藥學(xué)院，擔(dān)任副教授，2023年升任教授。主要研究非編碼RNA等生物大分子的功能及檢測。獲得國家自然科學(xué)基金、湖南省自然科學(xué)基金等多項(xiàng)經(jīng)費(fèi)支持。其科研成果受到了國內(nèi)及國際同行的認(rèn)可，在相關(guān)領(lǐng)域發(fā)表論文40多篇；其中包括Biosensors & Bioelectronics,、Small、Journal of Cell Biology、Oncogene、Cancer Letters等國際權(quán)威期刊，論文被引次數(shù)超過 1000次，影響h指數(shù)達(dá)19。授權(quán)國家發(fā)明專利2項(xiàng)。2018年榮獲湖南省青年骨干教師稱號(hào)，2022年獲得湖南省杰出青年基金項(xiàng)目。朱曲波積極參與學(xué)院及社會(huì)的各項(xiàng)工作。2013年以來，一直擔(dān)任湘雅藥學(xué)院青年科協(xié)副主席；2017-2021年擔(dān)任藥學(xué)院教授委員會(huì)副主任委員；2018至今擔(dān)任湘雅藥學(xué)院科研及對(duì)外交流辦副主任；2020年至今擔(dān)任中南大學(xué)動(dòng)物倫理委員會(huì)委員。此外，朱曲波副教授是中國細(xì)胞生物學(xué)會(huì)會(huì)員，中國藥理學(xué)會(huì)會(huì)員，湖南省腫瘤藥理學(xué)會(huì)委員，為學(xué)科發(fā)展貢獻(xiàn)力量。

受教育經(jīng)歷：

2003/12 –2009/05，Texas A&M University，生物科學(xué)及技術(shù)研究所，博士

1999/09 –2003/07，武漢大學(xué)，生科院藥學(xué)系，學(xué)士

研究工作經(jīng)歷：

2023/12-至今，中南大學(xué)，湘雅藥學(xué)院藥劑學(xué)系，教授

2011/09 –2023/12，中南大學(xué)，湘雅藥學(xué)院藥劑學(xué)系，副教授

2009/08 –2011/09，Case Western Reserve University，藥理學(xué)系，博士后

近5年承擔(dān)課題:

1. 國家自然科學(xué)基金面上項(xiàng)目，32270609，CPSF3通過抑制circRNA生成誘導(dǎo)肝癌發(fā)生發(fā)展的機(jī)制研究，2023/01-2026/12，54萬元，主持

2. 湖南省自然科學(xué)杰出青年基金項(xiàng)目，2022JJ10091，基于分支雜交鏈?zhǔn)椒磻?yīng)與脫氧核酶的腫瘤非編碼RNA檢測及篩選，2022/01-2025/12，50萬元，主持

3. 湖南省自然科學(xué)基金面上項(xiàng)目，2021JJ30916，CPSF30調(diào)節(jié)肝癌細(xì)胞中circRNA形成的機(jī)制研究，2021/01-2023/12，5萬，主持

4. 賽爾博克斯生物科技有限公司，H202105180720001，支原體檢測及清除試劑盒開發(fā)，2021/05-2023/12，32萬，主持

5. 湖南省自然科學(xué)基金面上項(xiàng)目，2018JJ2493，NUDT21調(diào)控肝癌中AGO2介導(dǎo)的microRNA基因沉默機(jī)制研究，2018/01-2020/12，5萬，主持

近5年發(fā)表論文：[1-42] 

[1] Z. Zeng, X. Zhou, R. Zhou, Z. Zeng, R. Sun, X. Zhang, H. Li, D. Zhang, Q. Zhu, C. Chen, Rational design of nonlinear hybridization immunosensor chain reactions for simultaneous ultrasensitive detection of two tumor marker proteins, Analytical Methods 15(11) (2023) 1422-1430.

[2] H. Ji, Q. Zhu, Application of intelligent responsive DNA self-assembling nanomaterials in drug delivery, Journal of controlled release : official journal of the Controlled Release Society 361 (2023) 803-818.

[3] Y. Huang, H. Ji, J. Dong, X. Wang, Z. He, Z. Cheng, Q. Zhu, CPSF3 Promotes Pre-mRNA Splicing and Prevents CircRNA Cyclization in Hepatocellular Carcinoma, Cancers 15(16) (2023).

[4] Y. Hu, X. Liu, F. Liu, J. Xie, Q. Zhu, S. Tan, Trehalose in Biomedical Cryopreservation-Properties, Mechanisms, Delivery Methods, Applications, Benefits, and Problems, Acs Biomaterials Science & Engineering 9(3) (2023) 1190-1204.

[5] C. Hu, M. Qiu, C. Yu, L. Yang, Q. Zhu, A. Liu, L. Du, C. Yang, The Impact of Air Source Heat Pump on the Production Performance of Broiler Chicks, Processes 11(5) (2023).

[6] Z. He, Q. Zhu, Circular RNAs: Emerging roles and new insights in human cancers, Biomedicine & Pharmacotherapy 165 (2023).

[7] J. Dong, Z. Zeng, Y. Huang, C. Chen, Z. Cheng, Q. Zhu, Challenges and opportunities for circRNA identification and delivery, Critical Reviews in Biochemistry and Molecular Biology  (2023).

[8] X. Cao, J. Dong, R. Sun, X. Zhang, C. Chen, Q. Zhu, A DNAzyme-enhanced nonlinear hybridization chain reaction for sensitive detection of microRNA, The Journal of biological chemistry 299(6) (2023) 104751-104751.

[9] X. Cao, C. Chen, Q. Zhu, Biosensors based on functional nucleic acids and isothermal amplification techniques, Talanta 253 (2023).

[10] Z. Zeng, R. Zhou, R. Sun, X. Zhang, D. Zhang, Q. Zhu, C. Chen, Nonlinear hybridization chain reaction-based flow cytometric immunoassay for the detection of prostate specific antigen, Analytica Chimica Acta 1220 (2022).

[11] Q. Ouyang, Y. Meng, W. Zhou, J. Tong, Z. Cheng, Q. Zhu, New advances in brain-targeting nano-drug delivery systems for Alzheimer's disease, Journal of Drug Targeting 30(1) (2022) 61-81.

[12] Q. Ouyang, K. Liu, Q. Zhu, H. Deng, Y. Le, W. Ouyang, X. Yan, W. Zhou, J. Tong, Brain-Penetration and Neuron-Targeting DNA Nanoflowers Co-Delivering miR-124 and Rutin for Synergistic Therapy of Alzheimer's Disease, Small 18(14) (2022).

[13] K. Liu, Y. Yin, Y. Le, O. Wen, A. Pan, J. Huang, Z. Xie, Q. Zhu, J. Tong, Age-related Loss of miR-124 Causes Cognitive Deficits via Derepressing RyR3 Expression, Aging and Disease 13(5) (2022) 1455-1470.

[14] R. Li, Q. Zhu, X. Wang, H. Wang, Mulberry leaf polyphenols alleviated high-fat diet-induced obesity in mice, Frontiers in Nutrition 9 (2022).

[15] R. Zhou, Z. Zeng, R. Sun, W. Liu, Q. Zhu, X. Zhang, C. Chen, Traditional and new applications of the HCR in biosensing and biomedicine, Analyst 146(23) (2021) 7087-7103.

[16] Z. Zeng, R. Zhou, R. Sun, X. Zhang, Z. Cheng, C. Chen, Q. Zhu, Nonlinear hybridization chain reaction-based functional DNA nanostructure assembly for biosensing, bioimaging applications, Biosensors & Bioelectronics 173 (2021).

[17] X. Wang, J. Dong, X. Li, Z. Cheng, Q. Zhu, CPSF4 regulates circRNA formation and microRNA mediated gene silencing in hepatocellular carcinoma, Oncogene 40(25) (2021) 4338-4351.

[18] Y. Su, B. Zhang, R. Sun, W. Liu, Q. Zhu, X. Zhang, R. Wang, C. Chen, PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application, Drug Delivery 28(1) (2021) 1397-1418.

[19] X. Liu, Y. Xu, F. Liu, Y. Pan, L. Miao, Q. Zhu, S. Tan, The Feasibility of Antioxidants Avoiding Oxidative Damages from Reactive Oxygen Species in Cryopreservation, Frontiers in Chemistry 9 (2021).

[20] X. Liu, H. Peng, J. Xie, Y. Hu, F. Liu, X. Wang, S. Yang, Z. Liu, Q. Zhu, S. Tan, Methods in Biosynthesis and Characterization of the Antifreeze Protein (AFP) for Potential Blood Cryopreservation, Journal of Nanomaterials 2021 (2021).

[21] X. Liu, Y. Pan, F. Liu, Y. He, Q. Zhu, Z. Liu, X. Zhan, S. Tan, A Review of the Material Characteristics, Antifreeze Mechanisms, and Applications of Cryoprotectants (CPAs), Journal of Nanomaterials 2021 (2021).

[22] Y. Huang, Q. Zhu, Mechanisms Regulating Abnormal Circular RNA Biogenesis in Cancer, Cancers 13(16) (2021).

[23] J. Dong, Z. Zeng, R. Sun, X. Zhang, Z. Cheng, C. Chen, Q. Zhu, Specific and sensitive detection of CircRNA based on netlike hybridization chain reaction, Biosensors & Bioelectronics 192 (2021).

[24] J. Dong, Z. Cheng, S. Tan, Q. Zhu, Clay nanoparticles as pharmaceutical carriers in drug delivery systems, Expert Opinion on Drug Delivery 18(6) (2021) 695-714.

[25] X. Li, X. Wang, Z. Cheng, Q. Zhu, AGO2 and its partners: a silencing complex, a chromatin modulator, and new features, Critical Reviews in Biochemistry and Molecular Biology 55(1) (2020) 33-53.

[26] X. Li, J. Ding, X. Wang, Z. Cheng, Q. Zhu, NUDT21 regulates circRNA cyclization and ceRNA crosstalk in hepatocellular carcinoma, Oncogene 39(4) (2020) 891-904.

[27] F. Li, X. Han, Y. Chen, S. Wang, Z. Cheng, G. Hu, W. Liu, Q. Zhu, In vitrometabolic characterization of orbitazine, a novel derivative of the PAC-1 anticancer agent, Journal of Pharmacy and Pharmacology 72(9) (2020) 1199-1210.

[28] J. Ding, W. Zhou, X. Li, M. Sun, J. Ding, Q. Zhu, Tandem DNAzyme for double digestion: a new tool for circRNA suppression, Biological Chemistry 400(2) (2019) 247-253.

近5年獲批專利:

(1) 譚淞文、謝靜嫻、朱曲波、劉祥健、劉鳳玲、王博、向佳、楊淑婷、趙宏麗、陳林、胡錢瑩；一種用于抗凍蛋白合成的生產(chǎn)方法及其設(shè)備，2021-5-18，中國，ZL202110550966.2 (發(fā)明專利)

(2) 朱曲波、李大力、童建斌、殷永佳；miR-124基因敲除小鼠動(dòng)物模型的構(gòu)建方法和應(yīng)用，2019-1-22，中國，ZL201610669402.X (發(fā)明專利)

省部級(jí)以上獲獎(jiǎng)：

(1) 朱曲波(1/1); 湖南省杰出青年, 湖南省科技廳, 2022

(2) 朱曲波(1/1); 湖南省青年骨干教師, 湖南省教育廳, 2018

(3) 歐陽琴，劉凱，朱曲波；湖南省自然科學(xué)優(yōu)秀學(xué)術(shù)論文二等獎(jiǎng)，湖南省自然科學(xué)學(xué)會(huì)研究會(huì)，2023