代書炎，男，特聘副教授，藥理學/結(jié)構(gòu)藥理學，碩士生導師
個人簡介
代書炎，男，1987年生，中南大學湘雅藥學院特聘副教授，碩士生導師。吉林大學學士，中國科學院生物物研究所博士（碩博連讀），中南大學湘雅醫(yī)院助理研究員、博士后。近5年發(fā)表SCI論文25篇，其中第一/通訊作者（含共同）論文8篇，包括Nature Communications 1篇、Nucleic Acids Research 2篇、高被引用論文1篇、封面文章1篇（Journal of Molecular Biology）；獲國家授權(quán)發(fā)明專利1項；作為副主編出版學術(shù)專著2本；主持湖南省科技廳項目、中國博士后基金項目、中南大學特聘人才科研啟動項目等5項，總經(jīng)費143萬；作為主要完成人獲湖南省醫(yī)學科技獎一等獎1項。
研究方向
1. 轉(zhuǎn)錄因子成靶潛力挖掘及新靶分子開發(fā)；
2. 轉(zhuǎn)錄因子在血腦屏障穩(wěn)態(tài)維持中的作用研究。
聯(lián)系方式
daishuyan@csu.edu.cn
代表性論文/著作
1. Dai S., Qu L., Li J., Zhang Y., Jiang L., Wei Hu., Guo M., Chen X., Chen Y.. Structural insight into the ligand binding mechanism of aryl hydrocarbon receptor. Nat Commun,2022;13, 6234.
2. Dai S, Qu L, Li J, Chen Y. Toward a mechanistic understanding of DNA binding by forkhead transcription factors and its perturbation by pathogenic mutations. Nucleic Acids Res. 2021;49:10235-49
3. Li J# , Dai S# , Chen X, Liang X, Qu L, Jiang L, et al. Mechanism of forkhead transcription factors binding to a novel palindromic DNA site. Nucleic Acids Res. 2021;49:3573-83.
4. Zhang H, Dai S*, Liang X, Li J*, Chen Y*. Mechanistic Insights into the Preference for Tandem Binding Sites in DNA Recognition by FOXM1. J Mol Biol. 2021;434:167426.
5. Dai S, Li J, Zhang H, Chen X, Guo M, Chen Z, et al. Structural Basis for DNA Recognition by FOXG1 and the Characterization of Disease-causing FOXG1 Mutations. J Mol Biol. 2020;432:6146-56.
6. Dai S, Zhou Z, Chen Z, Xu G, Chen Y. Fibroblast Growth Factor Receptors (FGFRs): Structures and Small Molecule Inhibitors. Cells. 2019;8.
7. Qu, L., Guo, M., Zhang, H., Chen, X., Wei, H., Jiang, L., Li, J., Chen, Z., Dai, S.*, and Chen, Y*. Characterization of the modification of Kelch-like ECH-associated protein 1 by different fumarates. Biochemical and Biophysical Research Communications. 2022; 12;605:9-15.
8. Dai S# , Sun C# , Tan K, Ye S, Zhang R. Structure of thrombospondin type 3 repeats in bacterial outer membrane protein A reveals its intra-repeat disulfide bond-dependent calcium-binding capability. Cell Calcium. 2017;66:78-89.
9.《醫(yī)學結(jié)構(gòu)蛋白質(zhì)組學》，湖南科學技術(shù)出版社，2021。（副主編）
10.《結(jié)構(gòu)蛋白質(zhì)組學研究在湘雅》，湖南科學技術(shù)出版社，2023。（副主編）
