中南大學(xué)，湘雅藥學(xué)院，副教授，博士生導(dǎo)師

電子郵箱：xyu226@csu.edu.cn

歡迎加入！長(zhǎng)期招聘博士后！

個(gè)人簡(jiǎn)介

2007年和2009年分別在北京大學(xué)藥學(xué)院獲得本科和碩士學(xué)位，2013年于德國(guó)馬爾堡大學(xué)藥物生物學(xué)和生物技術(shù)研究所獲得博士學(xué)位，之后依次在肯塔基大學(xué)藥學(xué)院和加州大學(xué)洛杉磯分校從事博士后研究。2016年入職中南大學(xué)湘雅藥學(xué)院，研究領(lǐng)域?yàn)槲⑸锾烊划a(chǎn)物生物合成和生物催化研究。

研究興趣

1. 微生物來(lái)源活性天然產(chǎn)物的生物合成研究

2. 微生物次級(jí)代謝產(chǎn)物的基因組挖掘

3. 天然產(chǎn)物及衍生物的生物催化研究。

主持科研項(xiàng)目

1. 國(guó)家自然科學(xué)基金面上項(xiàng)目，21877129，2019/01-2022/12，63萬(wàn)元，主持

2. 湖湘青年英才支持計(jì)劃，2020RC3007，2020/11-2023/10，50萬(wàn)元，主持

3. 國(guó)家自然科學(xué)基金青年基金項(xiàng)目，21708049，2018/01-2020/12，25萬(wàn)元，主持

代表性論文

1. D. Li^#, W. Wang^#, K. Xu^#, J. Li, B. Long, Z. Li, G. Tan, and X. Yu^*, Elucidation of a Dearomatization Route in the Biosynthesis of Oxysporidinone Involving a TenA-like Cytochrome P450 Enzyme, Angewandte Chemie International Edition, 2023, 62(25), e202301976. （影響因子16.6）

2. Y. Xu^#, D. Li^#, W. Wang, K. Xu, G. Tan, J Li, S.-M. Li, and X. Yu^*, Dearomative gem-diprenylation of hydroxynaphthalenes by an engineered fungal prenyltransferase, RSC Advances, 2022, 12, 27550.

3. S. Bao, X. Zhong, Y. Wan, G. Tan, K. Xu, and X. Yu^*, Synthesis of halogenated diphenylpiperazines from L-tyrosine derivatives by biotransformation, Chemistry Letters, 2022, 51, 13-15

4. S. Bao, L. Luo, Y. Wan, K. Xu, G. Tan, J. Fan, S.-M. Li, and X. Yu^*, Regiospecific 7-O-prenylation of anthocyanins by a fungal prenyltransferase, Bioorganic Chemistry, 2021, 110, 104787.

5. Y. Xu, D. Li, G. Tan, Y. Zhang, Z. Li, K. Xu, S.-M. Li, and X. Yu^*, A single amino acid switch alters the prenyl donor specificity of a fungal aromatic prenyltransferase toward biflavonoids, Organic Letters, 2021, 23(2), 497–502.

6. R. Wheeler^#, X. Yu^#, C. Hou^#, P. Mitra, J. Chen, F. Herkules, D. N. Ivanov, O. V. Tsodikov^*, and J. Rohr^*, Discovery of a cryptic intermediate in late steps of mithramycin biosynthesis, Angewandte Chemie International Edition, 2020, 59(2): 826-832.

7. K. Xu, C. Yang, Y. Xu, D. Li, S. Bao, Z. Zou, F. Kang, G. Tan, S.-M. Li and X. Yu^*, Selective geranylation of biflavonoids by Aspergillus terreus aromatic prenyltransferase (AtaPT), Organic & Biomolecular Chemistry, 2020, 18(1): 28-31.

8. C. Yang, Y. Xu, K. Xu, G. Tan, and X. Yu^*, Preparation of new halogenated diphenyl pyrazine analogs in Escherichia coli by a mono-module fungal nonribosomal peptide synthetase from Penicillium herquei, Tetrahedron Letters, 2018, 59(32): 3084-3087.

9. X. Yu, F. Liu, Y. Zou, M. Tang, L. Hang, K. N. Houk^*, and Y. Tang^*. Biosynthesis of Strained Piperazine Alkaloids: Uncovering the Concise Pathway of Herquline A, Journal of the American Chemical Society, 2016, 138, 13529–13532.

10. X. Yu, G. Zocher, X. Xie, M. Liebhold, S. Schütz, T. Stehle, and S.-M. Li^*. Catalytic mechanism of stereospecific formation of cis-configured prenylated pyrroloindoline diketopiperazines by indole prenyltransferases, Chemistry & Biology, 2013, 20, 1492-1501.

11. S. Yin^#, X. Yu^#, Q. Wang, X. Liu^*, and S.-M. Li^*. Identification of a brevianamide F reverse prenyltransferase BrePT from Aspergillus versicolor with a broad substrate specificity towards tryptophan-containing cyclic dipeptides, Applied Microbiology and Biotechnology, 2013, 97, 1649-1660.

12. X. Yu, Y. Liu, X. Xie, X. Zheng, and S.-M. Li^*. Biochemical characterization of indole prenyltransferases: filling the last gap of prenylation positions by a 5-dimethylallyltryptophansynthase from Aspergillus clavatus, Journal of Biological Chemistry, 2012, 287, 1371-1380.

13. X. Yu, A. Yang, W. Lin, and S.-M. Li^*. Friedel–Crafts alkylation on indolocarbazoles catalyzed by two dimethylallyltryptophan synthases from Aspergillus, Tetrahedron Letters, 2012, 53, 6861-6864.

14. X. Yu and S.-M. Li^*, Prenyltransferases of the dimethylallyltryptophan synthase superfamily, Methods in Enzymology, 2012, 516, 259-278.

15. X. Yu, and S.-M. Li^*, Prenylation of flavonoids by using a dimethylallyltryptophan synthase 7-DMATS from Aspergillus fumigatus, Chembiochem, 2011, 12(15), 2280-2283.

16. X. Yu, X. Xie, and S.-M. Li^*, Substrate promiscuity of secondary metabolite enzymes: prenylation of hydroxynaphthalenes by fungal indole prenyltransferases, Applied Microbiology and Biotechnology, 2011, 92, 737-748.

17. W. Yin^#, X. Yu^#, X. Xie, and S.-M. Li^*, Preparation of pyrrolo[2,3-b]indoles carrying a ?-configured reverse C3-dimethylallyl moiety by using a recombinant prenyltransferase CdpC3PT, Organic & Biomolecular Chemistry, 2010, 8, 2430-2438.