e-mail: Jieru.changer@gmail.com

教育背景:

2017 – 2022 博士

化學(xué)與分子生物學(xué)院，昆士蘭大學(xué)，布里斯班，圣盧西亞，昆士蘭州，澳大利亞

2016 – 2017 生物技術(shù)碩士

化學(xué)與分子生物學(xué)院，昆士蘭大學(xué)，布里斯班，圣盧西亞，昆士蘭州，澳大利亞

2014 – 2015 生物科學(xué)學(xué)士（榮譽(yù)學(xué)士）

皇家海軍學(xué)院，格林威治大學(xué)，帕克羅分校，倫敦，英格蘭

期刊文章 :

1. Jieru Yang, Huanmin Kang Yingyi Liu, Yan He*, Wenhu Zhou*, Harnessing Tumor Cell‐Derived Exosomes for Immune Rejection Management in Corneal Transplantation. Advanced Science,12(2),2025, 2409207.

2. Jiangxin Huang, Jieru Yang, Yuanying Yang, Shan Lu, Wenqun Li*, Wenhu Zhou*, Mitigating Doxorubicin‐Induced Cardiotoxicity and Enhancing Anti‐Tumor Efficacy with a Metformin‐Integrated Self‐Assembled Nanomedicine. Advanced Science, 2025, 2415227.

3. Jieru Yang, Jiaojiao Zhu, Shan Lu, Wenhu Zhou*, Transdermal psoriasis treatment inspired by tumor microenvironment-mediated immunomodulation and advanced by exosomal engineering. Journal of Controlled Release, 113664.

4. Shan Lu, Ze Mi, Jieru Yang, Peng Liu, Jinsong Ding, Jieru Yang* Pengfei Rong* and Wenhu Zhou*, Repolarizing Neutrophils via MnO2 Nanoparticle-Activated STING Pathway Enhances Salmonella-Mediated Tumor Immunotherapy. Journal of Nanobiotechnology, 22(1), 2025, 443.

5. Jieru Yang, Jennifer C. Boer, Mattaka Khongkow, Sarunya Phunpee, Zeinab G. Khalil, Sahra Bashiri, Cyril Deceneux et al. "The development of surface-modified liposomes as an intranasal delivery system for group a Streptococcus vaccines." Vaccines 11, no. 2 (2023): 305.https://doi.org/10.3390/vaccines11020305

6. Jieru Yang, Farrhana Firdaus, Armira Azuar, Zeinab G. Khalil, Nirmal Marasini, Robert J. Capon, Waleed M. Hussein, Istvan Toth, and Mariusz Skwarczynski. "Cell-penetrating peptides-based liposomal delivery system enhanced immunogenicity of peptide-based vaccine against Group A Streptococcus." Vaccines 9, no. 5 (2021): 499. https://doi.org/10.3390/vaccines9050499

7. Jieru Yang, Yacheng Luo, Mohini A. Shibu, Istvan Toth, and Mariusz Skwarczynskia. "Cell-penetrating peptides: efficient vectors for vaccine delivery." Current drug delivery 16, no. 5 (2019): 430-443.https://doi.org/10.2174/1567201816666190123120915

8. Dai, Charles C., Jieru Yang, Waleed M. Hussein, Lili Zhao, Xiumin Wang, Zeinab G. Khalil, Robert J. Capon, Istvan Toth, and Rachel J. Stephenson. "Polyethylenimine: An intranasal adjuvant for liposomal peptide-based subunit vaccine against group a streptococcus." ACS Infectious Diseases 6, no. 9 (2020): 2502-2512. https://doi.org/10.1021/acsinfecdis.0c00452

9. Zhao, Lili, Jieru Yang, Ummey Jannatun Nahar, Zeinab G. Khalil, Robert J. Capon, Waleed M. Hussein, Mariusz Skwarczynski, and Istvan Toth. "A dual-adjuvanting strategy for peptide-based subunit vaccines against group A Streptococcus: Lipidation and polyelectrolyte complexes." Bioorganic & Medicinal Chemistry 28, no. 24 (2020): 115823. https://doi.org/10.1016/j.bmc.2020.115823

10. Faruck, Mohammad O., Prashamsa Koirala, Jieru Yang, Michael J. D’Occhio, Mariusz Skwarczynski, and Istvan Toth. "Polyacrylate-GnRH peptide conjugate as an oral contraceptive vaccine candidate." Pharmaceutics 13, no. 7 (2021): 1081. https://doi.org/10.3390/pharmaceutics13071081

11. Dai, Charles C., Wenbin Huang, Jieru Yang, Waleed M. Hussein, Jingwen Wang, Zeinab G. Khalil, Robert J. Capon, Istvan Toth, and Rachel J. Stephenson. "Polyethylenimine quantity and molecular weight influence its adjuvanting properties in liposomal peptide vaccines." Bioorganic & Medicinal Chemistry Letters 40 (2021): 127920. https://doi.org/10.1016/j.bmcl.2021.127920

12. Dai, Chuankai, Zeinab G. Khalil, Waleed M. Hussein, Jieru Yang, Xiumin Wang, Lili Zhao, Robert J. Capon, Istvan Toth, and Rachel J. Stephenson. "Opsonic activity of conservative versus variable regions of the group a streptococcus M protein." Vaccines 8, no. 2 (2020): 210. https://doi.org/10.3390/vaccines8020210

13. Shalash, Ahmed O., Luke Becker, Jieru Yang, Paul Giacomin, Mark Pearson, Waleed M. Hussein, Alex Loukas, Mariusz Skwarczynski, and Istvan Toth. "Oral peptide vaccine against hookworm infection: correlation of antibody titers with protective efficacy." Vaccines 9, no. 9 (2021): 1034. https://doi.org/10.3390/vaccines9091034

14. Shalash, Ahmed O., Luke Becker, Jieru Yang, Paul Giacomin, Mark Pearson, Waleed M. Hussein, Alex Loukas, Istvan Toth, and Mariusz Skwarczynski. "Development of a peptide vaccine against hookworm infection: Immunogenicity, efficacy, and immune correlates of protection." Journal of Allergy and Clinical Immunology 150, no. 1 (2022): 157-169. https://doi.org/10.1016/j.jaci.2022.02.020

15. Azuar, Armira, Mohini A. Shibu, Nomin Adilbish, Nirmal Marasini, Hong Hung, Jieru Yang, Yacheng Luo et al. "Poly (hydrophobic amino acid) Conjugates for the Delivery of Multiepitope Vaccine against Group A Streptococcus." Bioconjugate Chemistry 32, no. 11 (2021): 2307-2317.https://doi.org/10.1021/acs.bioconjchem.1c00333

16. Firdaus, Farrhana Z., Stacey Bartlett, Waleed M. Hussein, Lantian Lu, Quentin Wright, Wenbin Huang, Ummey J. Nahar U.J. Jieru Yang et al. "Liposomal Formulations of a Polyleucine–Antigen Conjugate as Therapeutic Vaccines against Cervical Cancer." Pharmaceutics 15, no. 2 (2023): 602.https://doi.org/10.3390/pharmaceutics15020602

基金及資助 :

l 07.2023  EGCG-FA納米粒遞送CRISPR/Cas9基因編輯系統(tǒng)應(yīng)用開發(fā), 10萬，橫向

l 11.2022 博士后國際交流計(jì)劃引進(jìn)項(xiàng)目，60萬，湖南省人力資源和社會(huì)保障廳

l 07.2017 Awarded with a Research Higher Degree Scholarship, The University of Queensland，研究高等教育獎(jiǎng)學(xué)金，昆士蘭大學(xué)

l 07.2017 Awarded with a UQ Research Training Scholarship, The University of Queensland. UQ研究培訓(xùn)獎(jiǎng)學(xué)金，昆士蘭大學(xué)

l 02.2017 Awarded with a Dean’s Commendation for Academic Excellence, The University of Queensland. 成績卓越獎(jiǎng)，昆士蘭大學(xué)

l 06.2015 Awarded with First-Class Honours, University of Greenwich. 一等榮譽(yù)學(xué)位，格林威治大學(xué)

研究經(jīng)歷:

工作經(jīng)歷 :

學(xué)術(shù)活動(dòng)與會(huì)議:

1. Yang, J.; Firdaus, F.Z.; Skwarczynski, M.; Toth, I.; Delivery of a peptide-based vaccine against Group A Streptococcus with the help of cell-penetrating peptides, Drug Delivery Australia Virtual Meeting 2020, 23-11-2020. (Poster presentation)

2. Yang, J.; Firdaus, F.Z.; Azuar, B. A.; Skwarczynski, M.; Toth, I.; Delivery of a peptide-based vaccine against Group A Streptococcus with the help of cell-penetrating peptides, 8th Australasian Vaccines & Immunotherapeutics Development Meeting 2020, 9-10.11.2020. (Speed talk presentation).

3. Yang, J.; Azuar, B. A.; Skwarczynski, M.; Toth, I.; Delivery of a peptide-based vaccine against Group A Streptococcus with the help of cell-penetrating peptides, 16th Annual Research Student Symposium 2020, The University of Queensland, Brisbane, Australia, 26.11.2020. (Poster Presentation).

4. Yang, J..; Skwarczynski, M.; Toth, I.; Delivery of a peptide-based vaccine against Group A Streptococcus with the help of cell-penetrating peptides, 13th Australian Peptide Conference, Port Douglas, Australia, 08-13.09.2019. (Poster presentation)

5. Yang, J.; Azuar, B. A.; Skwarczynski, M.; Toth, I.; Delivery of a peptide-based vaccine against Group A Streptococcus with the help of cell-penetrating peptides, 15th Annual SCMB Research Students Symposium, Brisbane, Australia, 28.11.2019. (Poster presentation)

6. Yang, J.;; Skwarczynski, M.; Toth, I.; Delivery of a peptide-based vaccine against Group A Streptococcus with the help of cell-penetrating peptides, Drug Delivery Australia 2019 Conference, Brisbane, Australia, 18-19.11.2019. (Poster presentation)

7. Yang, J.; Azuar, B. A.; Skwarczynski, M.; Toth, I.; Development and delivery of a peptide-based vaccine against group A streptococcus with the help of cell penetrating peptide, The RACI Medicinal Chemistry and Chemical Biology Conference (MCCB), Brisbane, Australia, 18-21.11.2018. (Poster presentation)

實(shí)驗(yàn)技能：

· 納米粒子的合成與表征：熟練掌握制備多種納米粒子（如微乳液、脂質(zhì)體、聚合物納米粒子等）和表征技術(shù)（如動(dòng)態(tài)光散射、透射電子顯微鏡、原子力顯微鏡等）。

· 細(xì)胞培養(yǎng)和分子生物學(xué)技術(shù)：包括細(xì)胞培養(yǎng)、基因克隆、PCR、西方印跡等技術(shù)。

· 藥物釋放研究：能夠進(jìn)行體外和體內(nèi)藥物釋放實(shí)驗(yàn)，使用各種模型和技術(shù)進(jìn)行藥效和毒理學(xué)評估。

· 藥物動(dòng)力學(xué)和代謝研究：理解并應(yīng)用藥物動(dòng)力學(xué)模型和代謝研究的基本原理。

· 化合物的表征與純化：使用反相高效液相色譜（RP-HPLC, Shimadzu）和電噴霧電離質(zhì)譜（ESI-MS）進(jìn)行化合物的表征與純化。

· 動(dòng)物疫苗實(shí)驗(yàn)：通過皮下或鼻腔給藥途徑在小鼠模型上進(jìn)行免疫學(xué)研究。

· 固相肽合成：掌握微波輔助和手工固相肽合成技術(shù)（Boc或Fmoc）。

  數(shù)據(jù)分析技能：

· 統(tǒng)計(jì)軟件應(yīng)用：精通SPSS、R或其他統(tǒng)計(jì)軟件，能夠進(jìn)行高級(jí)數(shù)據(jù)分析和統(tǒng)計(jì)檢驗(yàn)。

· 圖像分析軟件：熟練使用ImageJ或其他相關(guān)軟件進(jìn)行細(xì)胞成像數(shù)據(jù)的分析。

· 計(jì)算機(jī)技能：熟練使用Chemdraw、Prism、Endnote等科學(xué)研究和文獻(xiàn)管理軟件。

  軟技能：

· 項(xiàng)目管理：能夠有效管理科研項(xiàng)目，包括時(shí)間管理、資源調(diào)配和團(tuán)隊(duì)協(xié)作。

· 科學(xué)寫作和溝通：具備撰寫科學(xué)論文、報(bào)告和申請書的能力，以及在學(xué)術(shù)會(huì)議上進(jìn)行口頭和海報(bào)展示的經(jīng)驗(yàn)。

· 團(tuán)隊(duì)協(xié)作和領(lǐng)導(dǎo)力：在多學(xué)科團(tuán)隊(duì)中工作的經(jīng)驗(yàn)，能夠領(lǐng)導(dǎo)小組或參與大型項(xiàng)目的合作。