謝努力，副教授。湖南大學(xué)博士，上海交通大學(xué)博士后（博后導(dǎo)師：樊春海院士）。博士期間獲得國家獎學(xué)金、校長獎學(xué)金等榮譽，曾獲國家留學(xué)基金委（CSC）公派獎學(xué)金資助，赴University of Michigan安娜堡分校以聯(lián)合培養(yǎng)博士研究生的身份交流學(xué)習(xí)2年。博士后期間獲得上海市”超級博士后“激勵計劃資助。現(xiàn)為中國化學(xué)會會員，芙蓉計劃衛(wèi)生健康高層次人才，湖南省生物醫(yī)學(xué)工程學(xué)會納米醫(yī)學(xué)與工程專委委員，《Exploration》期刊青年編委。主要從事核酸納米技術(shù)在分子計算、疾病診斷、新型藥物遞送和疾病治療等領(lǐng)域研究，以第一作者/通訊作者在Nature(二作)、JACS、Angew. Chem. Int. Ed.、ACS Nano、Adv. Sci.、Nano lett.、Chem. Sci.、Anal. Chem.、Chem. Commun.等國際知名期刊發(fā)表論文數(shù)十篇，其中一作論文10余篇， 論文總引次數(shù)達 2200次以上，H-index為22。

參與《藥劑學(xué)》、《藥物分析》、《藥劑學(xué)實驗》等課程教學(xué)活動，曾獲中南大學(xué)教學(xué)質(zhì)量優(yōu)秀獎（本科），指導(dǎo)學(xué)生獲得湖南省省級大學(xué)生創(chuàng)新訓(xùn)練項目1項。

主持國家自然科學(xué)基金青年項目 、湖南省自然科學(xué)基金青年項目 ，國家重點實驗室開放基金 ，中南大學(xué)科研啟動項目等科研項目。參與國家自然科學(xué)基金重點項目、面上項目多項。

ORCID:   https://orcid.org/0000-0002-8846-0532

研究方向及興趣：

1、基于DNA自組裝納米結(jié)構(gòu)的智能藥物遞送

2、DNA分子計算在癌癥和其他疾病上的智能、精準(zhǔn)診斷應(yīng)用

3、核酸與金屬相結(jié)合的納米材料制備及其皮膚相關(guān)疾病的治療

熱忱歡迎具有藥學(xué)、化學(xué)、化學(xué)生物學(xué)等學(xué)科背景的研究生或本科生加入研究團隊。

主要論文：

1. Hanane Aliouat, Detian Zhang, Lanyuan Peng, Jiaxin Huang, Hongshi Cheng, Jiaojiao Zhu, Xiang Chen, Nuli Xie^*, Wenhu Zhou^*, Shuang Zhao^*. Targeted DNA Nanomachine Enables Specific miRNA-Responsive Singlet Oxygen Amplification for Precise Cutaneous Squamous Cancer Therapy. Adv. Sci, 2025, DOI: 10.1002/advs.202415296.

2. Shiyuan Liu, Jiaoli Wang, Yu Chen, Jiahao Fan, Bin Du, Ruiting Liu, Xiaobei Zhu, Kemin Wang, Nuli Xie*, Jin Huang*. Modular Assembled Localized Hybridization Chain Reaction for In Situ mRNA Amplified Imaging [J]. Nano. Lett., 2024, 24, 37, 11590–11598.

3. Jing Wang, Nuli Xie, Shan Lu, Bo Xiao, Yangqin Ou, Qingnian Li, Dexian Liu, Wenhu Zhou*. CpG and Rutin Co‐Loaded DNA Tetrahedra for Targeted Therapy of Intracerebral Hemorrhage: Synergistic Hematoma Clearance and Neuroinflammation Inhibition. Adv. Funct. Matter. 2024, DOI:10.1002/adfm.202403469.

4. Hui Lv, Nuli Xie, Mingqiang Li, Mingkai Dong, Jiang Li, Xiaolei Zuo, Haibo Chen, Fei Wang*, Chunhai Fan*. Large-scale reconfigurable DNA-based logic gate for complex DNA computing. Nature 2023, 622, 292-300. (SCI一區(qū))

5. Zhenxiang Liu#, Nuli Xie#, Juan Li, Xiaoxiao Fu, Kemin Wang, Hui Shi*, Jin Huang*. Self-Priming DNA Polymerization-Propelled Stochastic Walkers on Magnetic Microbeads for Amplified Detection of miRNA. Anal. Chem. 2022, 95, 9, 4529-4535. (SCI一區(qū))

6. Nuli Xie, Huimin Wang, Xiaoxiao Fu, Jiaoli Wang, Jing Li, Kemin Wang, Jin Huang*. Dual amplification of bio-barcode and auto-cycling primer extension for highly sensitive detection of miRNA. Chem. Commun. 2022, 58, 73, 10221-10224. (SCI一區(qū))

7. Nuli Xie, Mingqiang Li, Yue Wang, Hui Lv, Jiye Shi, Jiang Li, Qian Li, Fei Wang*, Chunhai Fan. Scaling up multi-bit DNA full adder circuits with minimal strand displacement reactions. J. Am. Chem. Soc. 2022, DOI: 10.1021/jacs.2c03258. (SCI一區(qū))

8. Nuli Xie, Shiyuan Liu, Hongmei Fang, Yanjing Yang, Ke Quan, Jing Li, Xiaohai Yang, Kemin Wang, Jin Huang*. Three-dimensional molecular transfer from DNA nanocages to inner gold nanoparticle surfaces. ACS Nano 2019, 13, 4174-4182. (SCI一區(qū))

9. Nuli Xie, Haiyan Wang, Ke Quan, Feng Feng, Jin Huang*, Kemin Wang*. Self-assembled DNA-Based geometric polyhedrons: construction and applications. TrAC-Trends in Anal. Chem. 2020, 126, 115844. (SCI一區(qū))

10. Nuli Xie, Jin Huang*, Xiaohai Yang, Xiaoxiao He, Jianbo Liu, Jiaqi Huang, Hongmei Fang, Kemin Wang*. Scallop-inspired DNA nanomachine: a ratiometric nanothermometer for intracellular temperature sensing. Anal. Chem. 2017, 89, 12115-12122. (SCI一區(qū))

11. Nuli Xie, Jin Huang*, Xiaohai Yang, Yanjing Yang, Ke Quan, Min Ou, Hongmei Fang, Kemin Wang*. Competition-mediated FRET-switching DNA tetrahedron molecular beacon for intracellular molecular detection. ACS Sens. 2016, 12, 1445-1452. (SCI一區(qū))

12. Nuli Xie, Jin Huang*, Xiaohai Yang, Yanjing Yang, Ke Quan, He Wang, Le Ying, Min Ou, Kemin Wang*. A DNA tetrahedron-based molecular beacon for tumor-related mRNA detection in living cells. Chem. Commun. 2016, 52, 2346-2349. (SCI一區(qū))

13. Nuli Xie, Shiyuan Liu, Xiaohai Yang, Xiaoxiao He, Jin Huang*, Kemin Wang*. DNA tetrahedron nanostructures for biological applications: biosensors and drug delivery. Analyst 2017, 142, 3322-3332. (SCI二區(qū))

14. Le Ying #, Nuli Xie#, Yanjing Yang, Xiaohai Yang, Qifeng Zhou, Bincheng Yin, Jin Huang*, Kemin Wang*. A cell-surface-anchored ratiometric i-motif sensor for extracellular pH detection. Chem. Commun. 2016, 52, 7818-7821. (SCI一區(qū))

15. Hongmei Fang#, Nuli Xie#, Min Ou, Jin Huang, Wenshan Li, Qing Wang, Jianbo Liu, Xiaohai Yang*, Kemin Wang*. Detection of nucleic acids in complex samples via magnetic microbead-assisted catalyzed hairpin assembly and “DD-A” FRET. Anal. Chem. 2018, 90, 7164-7170. (SCI一區(qū))