鄧友超特聘副教授，1990年6月生，籍貫湖南省懷化市。2016年3月，獲中南大學(xué)化學(xué)化工學(xué)院制藥工程專業(yè)工學(xué)碩士，師從蔣玉仁教授；2019年6月，獲中南大學(xué)藥學(xué)專業(yè)醫(yī)學(xué)博士學(xué)位，師從沈奔教授、段燕文教授及黃勇教授；2019年8月- 2023年5月，美國(guó)普渡大學(xué)藥學(xué)院，從事表觀遺傳靶點(diǎn)（甲基/乙酰基轉(zhuǎn)移酶）小分子抑制劑的博士后研究工作，師從黃蓉教授。曾獲國(guó)家獎(jiǎng)學(xué)金，中南大學(xué)“優(yōu)秀研究生”，中南大學(xué)“優(yōu)秀博士畢業(yè)生”，“優(yōu)秀博士學(xué)位論文”等榮譽(yù)稱號(hào)。

研究方向：1.基于結(jié)構(gòu)（SBDD）的藥物設(shè)計(jì)方法研究；2.新型藥物篩選技術(shù)開(kāi)發(fā)；3.針對(duì)表觀遺傳類蛋白質(zhì)靶點(diǎn)的小分子藥物研究，如PCMT1,PARPs,PRMT以及NATs。主持中南大學(xué)博士生創(chuàng)新科研項(xiàng)目一項(xiàng)，中南大學(xué)校級(jí)引才支持基金一項(xiàng)，國(guó)家自然科學(xué)青年基金一項(xiàng)。近五年，以第一作者及通訊作者發(fā)表SCI收錄文章10篇，其中藥物化學(xué)專業(yè)頂刊6篇。

科研成果媒體報(bào)道鏈接：

1. The Purdue College of Pharmacy is pleased to honor and recognize the outstanding research and scholarship generated by our faculty each month. This month we highlight Drs. Youchao Deng, Postdoc in Medicinal Chemistry and Molecular Pharmacology, and Rong Huang, Professor of Medicinal Chemistry and Molecular Pharmacology, for their recent publication, " Structure–Activity Relationship Studies of Venglustat on NTMT1 Inhibition", which can be read in the Journal of Medicinal Chemistry (January, 2023; DOI: 10.1021/acs.jmedchem.2c01854).

https://www.pharmacy.purdue.edu/news/2023/05/08/monthly-publication-highlight-drs-deng-and-huang

2. 普渡大學(xué)黃蓉團(tuán)隊(duì)報(bào)道α-N-末端甲基轉(zhuǎn)移酶NTMT1的體內(nèi)活性小分子抑制劑.

https://www.x-mol.com/news/842346

3. 普渡大學(xué)黃蓉團(tuán)隊(duì)報(bào)道α-N-末端甲基轉(zhuǎn)移酶的小分子抑制劑.

https://www.x-mol.com/news/785483

4. 普渡大學(xué)黃蓉團(tuán)隊(duì)報(bào)道α-N-末端乙酰基轉(zhuǎn)移酶D的新型抑制劑.

https://www.x-mol.com/news/683908

5. 中南大學(xué)湘雅國(guó)際轉(zhuǎn)化醫(yī)學(xué)聯(lián)合研究院在抗感染新藥研發(fā)上取得新進(jìn)展.

https://news.csu.edu.cn/info/1003/139635.htm

代表性研究論文：

1. Deng Y, Song X, Iyamu ID, et al. A unique binding pocket induced by a noncanonical SAH mimic to develop potent and selective PRMT inhibitors. Acta Pharmaceutica Sinica B, 2023. (中科院一區(qū)，Top 期刊，IF 14.5)

2. Deng Y, Deng S, Ho Y H, et al. Novel bisubstrate inhibitors for protein N-terminal acetyltransferase D[J]. Journal of Medicinal Chemistry, 2021, 64: 8263-8271. (中科院一區(qū)，Top 期刊，IF 8.06)

3. Dong G^#, Deng Y^#, Yasgar, A, et al. Venglustat Inhibits Protein N-Terminal Methyltransferase 1 in a Substrate-Competitive Manner[J]. Journal of Medicinal Chemistry, 2022, 65: 12334-12345. ( 中科院一區(qū)，Top 期刊, IF 8.06)

4. Deng Y, Weng X, Li Y, et al. Late-stage functionalization of platensimycin leading to multiple analogues with improved antibacterial activity in vitro and in vivo[J]. Journal of medicinal chemistry, 2019, 62: 6682-6693. (中科院一區(qū)，Top 期刊, IF 8.06)

5. Deng Y, Su M, Kang D, et al. Semisynthesis of platensimycin derivatives with antibiotic activities in mice via Suzuki–Miyaura cross-coupling reactions[J]. Journal of medicinal chemistry, 2018, 61: 11341-11348. (中科院一區(qū)，Top 期刊, IF 8.06)

6. Deng Y, Dong G, Meng Y, et al. Structure–Activity Relationship Studies of Venglustat on NTMT1 Inhibition[J]. Journal of Medicinal Chemistry, 2023, 66: 1601–1615. (中科院一區(qū)，Top 期刊, IF 8.06)

7. Deng Y, Kang D, Shi J, et al. The semi-synthesis, biological evaluation and docking analysis of the oxime, hydrazine and hydrazide derivatives of platensimycin[J]. MedChemComm, 2018, 9: 789-794.（封面, JCR Q2, IF 3.6）

8. Deng Y, Li Y, Wen Z, et al. Morphing Natural Product Platensimycin via Heck, Sonogashira, and One-Pot Sonogashira/Cycloaddition Reactions to Produce Antibiotics with In Vivo Activity[J]. Antibiotics, 2022, 11, 425. (JCR Q2, IF 5.2)

9. Zhou, J^#, Deng Y^#, et al. Comparative study of adenosine analogs as inhibitors of protein arginine methyltransferases and a Clostridioides difficile-specific DNA adenine methyltransferase[J]. ACS Chemical Biology, 2023. (JCR Q1, IF 4.6)

10. Al-Hamashi A A, Chen D, Deng Y, et al. Discovery of a potent and dual-selective bisubstrate inhibitor for protein arginine methyltransferase 4/5[J]. Acta Pharmaceutica Sinica B, 2020, 1: 2709-2718. (Top 期刊, IF 14.9)

11. Cao D, Yang J, Deng Y, et al. Discovery of a mammalian FASN inhibitor against xenografts of non-small cell lung cancer and melanoma[J]. Signal Transduction and Targeted Therapy, 2022, 7: 1-4. (Top 期刊, IF 38.1)

12. Dong L B, Rudolf J D, Kang D, et al. Biosynthesis of thiocarboxylic acid-containing natural products[J]. Nature communications, 2018, 9: 1-10. (Top 期刊, IF 17.6)

聯(lián)系方式：

dengyouchao@csu.edu.cn;

dengyouchao1206@163.com;

https://scholar.google.com/citations?user=Wb8cfM4AAAAJ&hl=en;

https://www.researchgate.net/profile/Youchao-Deng;